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Alexander M Dizhoor Selected Research

Retinal Degeneration

10/2021Retinal degeneration-3 protein attenuates photoreceptor degeneration in transgenic mice expressing dominant mutation of human retinal guanylyl cyclase.
1/2019Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.
1/2019A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration.
1/2019Retinal degeneration 3 (RD3) protein, a retinal guanylyl cyclase regulator, forms a monomeric and elongated four-helix bundle.
1/2018Chemical shift assignments of retinal degeneration 3 protein (RD3).
1/2016Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.
8/2015Dimerization Domain of Retinal Membrane Guanylyl Cyclase 1 (RetGC1) Is an Essential Part of Guanylyl Cyclase-activating Protein (GCAP) Binding Interface.
11/2011Retinal degeneration 3 (RD3) protein inhibits catalytic activity of retinal membrane guanylyl cyclase (RetGC) and its stimulation by activating proteins.
12/2009Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark.
8/2007Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark.

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Alexander M Dizhoor Research Topics

Disease

11Blindness (Hysterical Blindness)
10/2022 - 08/2015
10Retinal Degeneration
10/2021 - 08/2007
5Leber Congenital Amaurosis
10/2022 - 02/2010
4Cone-Rod Dystrophies
12/2020 - 11/2016
2Retinal Dystrophies
01/2021 - 02/2010
2Night Blindness (Nyctalopia)
12/2020 - 11/2008
2type 1 Amaurosis congenita of Leber
01/2016 - 01/2013
2Retinal Diseases
04/2014 - 01/2012
1Retinal cone dystrophy 2
10/2021
1congenital stationary Night blindness
12/2020
1Photophobia (Light Sensitivity)
01/2010

Drug/Important Bio-Agent (IBA)

20Retinaldehyde (Retinal)IBA
10/2021 - 08/2007
18Guanylate Cyclase (Guanylyl Cyclase)IBA
10/2021 - 08/2007
15Proteins (Proteins, Gene)FDA Link
10/2021 - 11/2011
9CalciumIBA
10/2021 - 12/2009
7Guanylate Cyclase-Activating ProteinsIBA
01/2020 - 01/2010
3IsoenzymesIBA
10/2021 - 01/2012
2EnzymesIBA
01/2016 - 04/2014
2Phosphotransferases (Kinase)IBA
03/2015 - 02/2010
1Cyclic GMPIBA
10/2022
1Staphylococcal Protein A (Protein A)IBA
01/2019
1Carrier Proteins (Binding Protein)IBA
11/2011
1Rhodopsin (Visual Purple)IBA
11/2008

Therapy/Procedure

1Therapeutics
01/2013